Group Xiang

Lab PI

Xiang Kuanhui, Associate Researcher/Assistant Professor, Doctoral Advisor at the Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University, Deputy Director of the Peking University-YHLO Joint Laboratory, selected for the Beijing Association for Science and Technology Youth Talent Support Program.

Email: kxiang@bjmu.edu.cn

Education

2014.09-2016.08: Rockefeller University, USA, Nobel Laureate Charles M. Rice's Laboratory, Joint Training

2011.09-2017.07: Peking University, Microbiology and Infectious Disease, Ph.D.

2006.09-2011.07: Hebei Medical University, Medical Laboratory Science, Bachelor's Degree

Work Experience

2022.08-Present: Peking University, Pathogen Biology, Associate Researcher

2017.08-2022.07: Peking University, Pathogen Biology, Lecturer

Academic Service and Awards

Young Member of the Youth Committee of the Infectious Disease Branch of the Chinese Preventive Medicine Association

Member of the First Committee of the Vaccine Basic Research Professional Committee of the China Vaccine Industry Association

Editorial Board Member of Scientific Reports

Young Editorial Board Member of JCTH Journal

Projects

Principal investigator of 2 National Natural Science Foundation projects, and 5 other fund and horizontal projects

Applied for 8 Chinese invention patents, 5 of which have been approved

Research Focus

Long-term commitment to the establishment and optimization of virus infection and pathogenesis models, interaction between viruses and hosts, and antiviral drug screening.

Established a highly efficient HBV infection cell model for virus infection and antiviral drug screening and evaluation. Discovered that TRIM56 mediated by interferon inhibits HBV replication by ubiquitinating the NF-κB pathway to suppress HBV core promoter activity.

Investigated the effects of HBV S gene mutations on virus infection, replication, and secretion, revealing new mechanisms of virus evasion from the host.

First to discover that components of breast milk (lactoferrin, mucin 1, etc.) have significant anti-SARS-CoV-2 effects and collaborated to find that traditional Chinese medicine components inhibit SARS-CoV-2 infection by blocking its receptor binding, providing a basis for subsequent drug development.

Published 31 SCI papers, with articles in journals such as J Hepatol, Signal Transduct Target Ther, Stem Cell Rep, and Antivir Res.

Achievements include the Second Prize of the Chinese Medical Science and Technology Award (5/11), the First Prize of the Peking University Youth Post Master/Excellent Teaching Achievement Award (2/8) in 2021, Outstanding Class Advisor of Peking University in 2022, Outstanding Graduate of Beijing Municipality, Outstanding Graduate of Peking University, and Outstanding Doctoral Dissertation of Peking University in 2017.

Representative Achievements (# co-first author, * corresponding author):

1. Kuanhui Xiang, Eleftherios Michailidis, Hai Ding, Ya-Qin Peng, Ming-Ze Su, Yao Li, Xue-En Liu, Viet Loan Dao Thi, Xian-Fang Wu, William M Schneider, Charles M Rice, Hui Zhuang*, Tong Li *. Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA. Journal of Hepatology, 2017, 66(2):288-296 (IF: 30.08)

2. Huahao Fan#, Bixia Hong#, Yuqian Luo#, Qi Peng#, Liqin Wang, Xiangshu Jin, Yangzhen Chen, Yunjia Hu, Yi Shi, Tong Li, Hui Zhuang, Yi-Hua Zhou*, Yigang Tong*, Kuanhui Xiang*. The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro. Signal Transduction and Targeted Therapy, 2020, 5(1):275 (Research Letter, IF：38.1)

3. Xinyuan Lai#, Chuanyun Li#, Chengang Xian, Zihang Pan, Kai Zhang, Lei Wang, Bingqing Xie, Junning Cao, Jihang Shi, Juan Deng, Shichun Lu, Hongkui Deng, Hui Zhuang, Tong Li1*, Yan Shi3*, Kuanhui Xiang*. Generation of functionally competent hepatic stellate cells from human stem cells to model liver fibrosis in vitro. Stem Cell Reports, 2022, 17:1-17 (IF:7.29, Top)

4. Yang Yi#, Junhua Li#, Xinyuan Lai#, Meng Zhang, Yi Kuang, Yang-Oujie Bao, Rong Yu, Wei Hong, Elishiba Muturi, Heng Xue, Hongping Wei, Tong Li, Hui Zhuang, Xue Qiao, Kuanhui Xiang*, Hang Yang*, Min Ye*. Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection. Journal of Advanced Research, 2021, 36:201-210 (IF: 12.82)

5. Kai Zhang#, Xinyuan Lai#, Ji Song, Lingyuan He, Luwei Wang, Guomin Ou, Xing Tian, Lei Wang, Juan Deng, Jiajia Zhang, Chuanyun Li, Hui Zhuang*, Tong Li*, Kuanhui Xiang*. A novel cell culture model reveals the viral interference during hepatitis B and C virus coinfection. Antiviral Research, 2021, 189:105061 (IF: 10.1)

6. Xing Tian#, Huijun Dong#, Xinyuan Lai, Guomin Ou, Junning Cao, Jihang Shi, Chengang Xiang, Lei Wang, Xuechao Zhang, Kai Zhang, Ji Song, Juan Deng, Hongkui Deng, Shichun Lu, Hui Zhuang*, Tong Li*, Kuanhui Xiang*. TRIM56 impairs HBV infection and replication by inhibiting HBV core promoter activity. Antiviral Research, 2022, 105406 (IF: 10.1)

7. Xinyuan Lai#, Yanying Yu#, Wei Xian#, Fei Ye#, Xiaohui Ju, Yuqian Luo, Huijun Dong, Yi-Hua Zhou, Wenjie Tan, Hui Zhuang, Tong Li, Xiaoyun Liu*, Qiang Ding*, Kuanhui Xiang*. Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication. iScience, 2022, 25(4): 104136 (IF: 6.11)

8. Yuqian Luo#, Kuanhui Xiang#, Jingli Liu, Ji Song, Jing Feng, Jie Chen, Yimin Dai, Yali Hu, Hui Zhuang*, Yihua Zhou*. Inhibition of In Vitro Infection of Hepatitis B Virus by Human Breastmilk. Nutrients, 2022, 14(8):1561 (IF: 6.71)

9. Chengang Xiang#, Yuanyuan Du#, Gaofan Meng#, Liew Soon Yi, Shicheng Sun, Nan Song, Xiaonan Zhang, Yiwei Xiao, Jie Wang, Zhigang Yi, Yifang Liu, Bingqing Xie, Min Wu, Jun Shu, Da Sun, Jun Jia, Zhen Liang, Dong Sun, Yanxiang Huang, Yan Shi, Jun Xu, Fengmin Lu, Cheng Li, Kuanhui Xiang, Zhenghong Yuan*, Shichun Lu*, Hongkui Deng*. Long-term functional maintenance of primary human hepatocytes in vitro. Science, 2019, 364(6438):399-402 (IF: 63.71)

10. Xianfang Wu#, Viet Loan Dao Thi#, Peng Liu, Constantin N Takacs, Kuanhui Xiang, Linda Andrus, Jérôme Gouttenoire, Darius Moradpour, Charles M Rice. Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems. Gastroenterology, 2018, 154(3): 663-674 (IF: 33.88)