实验室PI

王麟，北京大学医学部博士生导师，副研究员。以通讯作者在Gastroenterology（2024）、JVI（2024）、EMI（2024）、Hepatology（2023, 2022a, 2022b）和Antiviral Research等领域专业期刊发表研究论著。作为编委参编国际首部HEV英文专著《Hepatitis E Virus》。入选中国科协青托举、北京“高创人才”计划，主持国家重点研发计划课题、国家自然科学基金项目。中华预防医学会感染性疾病防控分会委员、中国微生物学会病毒学分会青委。

主要研究方向：主要从事戊型肝炎病毒（HEV）为代表的人兽共患病毒跨种系传播和致病机制研究：建立了可模拟临床戊肝患者急性和慢性疾病表现的HEV感染沙鼠模型及兔模型，为研究多种基因型HEV的跨种传播及致病机制领域提供了重要的模型工具。

目前主要兴趣集中在：

1. 重要人类病毒小鼠感染模型建立

2. 人兽共患病毒跨种传播及宿主限制性因子研究。

代表性研究成果

1) Liu T, He Q, Yang X, Li Y, Yuan D, Lu Q, Tang T, Guan G, Zheng L, Zhang H, Xia C, Yin X, Wei G, Chen X, Lu F, Wang L*. An Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection.  Gastroenterology . 2024. doi:10.1053/j.gastro.2024.03.038. (With  Editorials )

2) He Q, Liu T, Yang X, Yuan D, Lu Q, Li Y, Zhang H, Liu X, Xia C, Sridhar S, Tian L, Liu X, Meng L, Ning J, Lu F, Wang L, Yin X, Wang L*. Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits.  J Virol . 2024. Accept.

3) He Q, Zhang F, Shu J, Li S, Liang Z, Du M, Liu X, Liu T, Li M, Yin X, Pan Q, Lu F*, Wang L*, Wang L*. Immunocompromised rabbit model of chronic HEV reveals liver fibrosis and distinct efficacy of different vaccination strategies.  Hepatology . 2022;76(3):788-802. doi:10.1002/hep.32455. (Featured Article)

4) Liu T#, Cao Y#, Weng J, Gao S, Jin Z, Zhang Y, Yang Y, Zhang H, Xia C, Yin X, Luo Y, He Q, Jiang H*, Wang L*, Zhang Z*. Hepatitis E virus infects human testicular tissue and Sertoli cells.  Emerg Microbes Infect . 2024;13(1):2332657. doi:10.1080/22221751.2024.2332657.

5) Ying D#, He Q#, Tian W#, Chen Y#, Zhang X, Wang S, Liu C, Chen Z, Liu Y, Fu L, Yan L, Wang L, Tang Z*, Wang L*, Zheng Z*, Xia N*. Urine is a viral antigen reservoir in hepatitis E virus infection.  Hepatology . 2023;77(5):1722-1734. doi:10.1002/hep.32745. (With  Editorials )

6) Li Y, Yu P, Kessler AL, Shu J, Liu X, Liang Z, Liu J, Li Y, Li P, Wang L, Wang Y, Ma Z, Liu A, Wang L, Bruno MJ, de Man RA, Peppelenbosch MP, Buschow SI, Wang L*, Wang Y*, Pan Q*. Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable.  Hepatology . 2022;75(1):196-212. doi:10.1002/hep.32114.

7) Liang Z#, Shu J#, He Q, Zhang F, Dai L, Wang L*, Lu F*, Wang L*. High dose sofosbuvir and sofosbuvir-plus-ribavirin therapy inhibit Hepatitis E Virus (HEV) replication in a rabbit model for acute HEV infection.  Antiviral Res . 2022 Mar;199:105274. doi: 10.1016/j.antiviral.2022.105274.