个人简介：

陈香梅，副教授，博士生导师。在国家自然科学基金、科技部重大专项和北京市自然科学基金等课题资助下，围绕肝炎病毒和肝癌，鉴定了多个调控HBV复制和影响HBV治疗转归的关键宿主基因，深入探究了HBV整合致癌的机制，建立了靶向HBV cccDNA的工程化细胞囊泡Cas9/gRNA递送系统。以通讯作者在Journal of Hepatology、Signal Transduction and Targeted Therapy和Hepatology等权威期刊发表研究论文40余篇。获得国家科技进步二等奖（第8完成人）、中华医学科技二等奖（第2完成人）、北京大学优秀党员、北京大学医学部教学优秀奖等奖励和荣誉称号。

主要研究方向：

病毒性肝炎及肝癌。本课题组聚焦慢性乙肝分子病毒学及临床治愈中的关键科学问题，通过解析HBV生命周期的关键环节、探究病毒整合致癌的分子机制、寻找影响临床治愈的关键因素以及挖掘新的抗病毒药物靶点和技术，为阐明乙肝相关疾病的发病机制、优化慢性乙肝的治愈策略等提供了重要依据。

联系方式：

Email: xm_chen6176@bjmu.edu.cn

主要代表作：

1. Zhang T^#, Zheng H^#, Lu D^#, Guan G, Li D, Zhang J, Liu S, Zhao J, Guo JT*, Lu F*, Chen X*. RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation. Signal Transduct Target Ther. 2023,13;8(1):346.

2. Guan G^#, Zhang T^#, Ning J^#, Tao C^#, Gao N^#, Zeng Z, Gao H, Chen C, Yang J, Zhang J, Gu W, Yang E, Liu R, Guo X, Ren S, Wang L, Wei G, Zheng S, Gao Z*, Chen X*, Lu F*, Chen X*. Higher TP53BP2 expression is associated with HBsAg loss in peginterferon-alpha-treated chronic hepatitis B. J Hepatol. 2023,17:S0168-8278(23)05175-9.

3. Liu Y^#, Liu H^#, Hu Z^#, Ding Y^#, Pan XB, Zou J, Xi J, Yu G, Huang H, Luo MT, Guo F, Liu S, Sheng Q, Jia J, Zheng YT, Wang J, Chen X*, Guo JT*, Wei L*, Lu F*. Hepatitis B virus virions produced under nucleos(t)ide analogue treatment are mainly not infectious because of irreversible DNA chain termination. Hepatology. 2020,71(2):463-476.

4. Li X^#, Zhang J^#, Yang Z, Kang J, Jiang S, Zhang T, Chen T, Li M, Lv Q, Chen X*, McCrae MA, Zhuang H, Lu F*. The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma. J Hepatol. 2014,60(5):975-84.

5. Guan G, Zou J, Zhang T, Lu F*, Chen X*. A global survey of alternative splicing of HBV transcriptome using long-read sequencing. J Hepatol. 2022,76(1):234-236.

6. Ning J^#, Wang J^#, Zheng H, Peng S, Mao T, Wang L, Yu G, Liu J, Liu S, Zhang T, Ding S*, Lu F*, Chen X*. Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups. Emerg Microbes Infect. 2022,11(1):1356-1370.

7. Zeng W, Zheng L, Li Y, Yang J, Mao T, Zhang J, Liu Y, Ning J, Zhang T, Huang H, Chen X*, Lu F*. Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration. Emerg Microbes Infect. 2023,20:2284286.

8. Yang D^#, Zou J^#, Guan G^#, Feng X^#, Zhang T, Li G, Liu H, Zheng H, Xi J, Yu G, Dai L*, Lu F*, Chen X*. The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome.  J Med Virol. 2023,95(10):e29129.

9. Wu F^#, Zheng H^#, Wang W, Wu Q, Zhang Q, Guo J, Pu B, Shi X, Li J*, Chen X*, Hong W*. Rapid eradication of antibiotic-resistant bacteria and biofilms by MXene and near-infrared light through photothermal ablation.  Science China- Materials . 2021,64(03):748-758.

10. Zao X^#, Cheng J^#, Shen C, Guan G, Feng X, Zou J, Zhang J, Liu T, Zheng H, Zhang T, Wang J, Liu J, Li D, Lu F*, You F*, Chen X*. NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription.  Oncoimmunology. 2021,10:1869388.