教师队伍
沈 弢 副教授
沈弢,男,副教授,博士研究生导师。邮箱:taoshen@hsc.pku.edu.cn
教育经历
2002.09-2005.07 中国疾病预防控制中心 艾防中心 免疫学 博士
1999.09-2002.07 卫生部武汉生物制品研究所 病原生物学 硕士
1989.09-1994.07 蚌埠医学院 医学检验系 本科
工作经历
2012.08至今:北京大学基础医学院 病原生物学系 副教授
2009.01-2012.08 北京大学基础医学院 病原生物学系 讲师
2006.05-2009.01 The Cleveland Clinic、Case Western Reserve University博士后
2005.08-2006.5 温州医学院 微生物和免疫学教研室讲师
学术服务及获奖
1) 北京微生物学会第11、12届理事会理事(2017-2025)
2) 中国疫苗行业协会疫苗基础研究专业委员会常务委员(2022-2027)
3) 《中华微生物学和免疫学杂志》第七届、第八届编辑委员会编委(2013-2028)
4) 《中国输血杂志》第八届、第九届编辑委员会编委(2018-2025)
5) 中华预防医学会血液安全专业委员会委员(2020-2025)
6) 中国性病艾滋病防治协会HIV病毒学专业委员会委员(2020-2025)
7) 中国性病艾滋病防治协会HIV合并肝炎专业委员会委员(2020-2025)
8) 中华医学会肝病学分会肝病基础医学与实验协作组成员(2020-2025)
研究概述:
主要从事HIV和SARS-CoV-2相关的感染免疫学和分子诊断学研究,在感染性疾病分子诊断试剂研发和质量评价以及微生物富集策略等研究领域有丰富的经验。以第一或通讯作者在 Gastroenterology 、 Cell Mol Immunol 、 J Hepatol 、 J Infect 、 J Med Virol 发表中英文论文70余篇,其中SCI论文41篇,论文合计他引次数超过1300次。合作开发SARS-CoV-2、HDV有关新型诊断试剂,并取得较好的社会效应和经济效应。
近年来承担主要研究项目:
生物安全专项课题“微生物富集新技术研发”(SWAQ-2021-01)(2021.1-2024.7)
国家自然基金面上项目“封闭免疫检查点NKG2A增强NK和T细胞介导的细胞毒效应以清除HIV-1潜伏感染的研究”(批准号:82072277)(2021.1-2024.12)
北京市自然基金面上专项“成人重症COVID-19易感性的基因多态性研究”(批准号:M21021)(2021.1-2023.12)
北大-亚辉龙感染性疾病分子诊断联合实验室(1000万元)(2021.9-2024.9)
中国肝炎防治基金会课题“新型生物标志物诊断CHB感染者显著肝组织病理损伤的意义”(批准号:GRG202301)(2023-2025)(50万元)
代表性研究成果:
1. Yue Yin#, Xinjie Li#, Chungen Qian, Bangning Cheng, Fengmin Lu, Tao Shen*. Antibody efficacy of inactivated vaccine boosters (CoronaVac) against Omicron variant from a 15-month follow-up study. Journal of Infection, 2022, 85(4): e119-e121.
2. Xinjie Li#, Yuqi Zhang#, Jie Wang, Jun Han*, Tao Shen*. Long-term dynamic shifts in genomic base content and evolutionary trajectories of SARS-CoV-2 variant. Journal of Medical Virology, 2023, 95(10): e29128.
3. Xinjie Li#, Yue Yin#, Qianqian Cui#, Weijin Huang, Qinghua Zou*, Tao Shen*. Long-term variations and potency of neutralizing antibodies against Omicron subvariants after CoronaVac inactivated booster: a 7-month follow-up study. Journal of Medical Virology, 2023, 95(1): e28279.
4. Xinjie Li#, Yue Yin#, Ling Pang, Shuyun Xu, Fengmin Lu, Dong Xu, Tao Shen*. Colloidal gold immunochromatographic assay (GICA) is an effective screening method for identifying detectable anti-SARS-CoV-2 neutralizing antibodies. International Journal of Infectious Diseases. 2021, 108: 483-486.
5. Tao Shen#, Yingxia Liu#, Jia Shang#, Qing Xie, Jun Li, Ming Yan, Jianming Xu, Junqi Niu, Jiajun Liu, Paul B. Watkins, Guruprasad P. Aithal, Raúl J. Andrade, Xiaoguang Dou, Lvfeng Yao, Fangfang Lv, Qi Wang, Yongguo Li, Xinmin Zhou, Yuexin Zhang, Peilan Zong, Bin Wan, Zhengsheng Zou, Dongliang Yang, Yuqiang Nie, Dongliang Li, Yuya Wang, Xi’an Han, Hui Zhuang, Yimin Mao*, Chengwei Chen*, Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology, 2019, 156(8): 2230-2241.
6. Wang Jie#, Shen Tao#, Huang Xiangbo#, G. Renuka Kumar, Xiangmei Chen, Zhenzhen Zeng, Ruiyang Zhang, Ran Chen, Tong Li, Tianying Zhang, Quan Yuan, Pao-Chen Li, Qi Huang, Richard Colonno, Jidong Jia, Jinlin Hou, Malcolm A. McCrae, Zhiliang Gao(*), Hong Ren(*), Ningshao Xia(*), Hui Zhuang and Fengmin Lu*, Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound, Journal of Hepatology, 2016, 65(4): 700-710.
7. Maermaer Tuohutaerbieke#, Xinjie Li#, Yue Yin, Wei Chen, Dongmei Wu, Zhize Mao, Jiamixi Mamuerjiang, Yimin Mao*, Tao Shen*. The Characteristics, Prevalence, and Risk Factors of Drug-Induced Liver Injury among Brucellosis Inpatients in Xinjiang, China. Frontiers in Pharmacology. 2021, (12): 657805.
8. Zhe Xie#, Jiajia Zheng#, Yuya Wang, Dan Li, Tuohutaerbieke Maermaer, Yuantao Li, Jing Tu, Qiang Xu, Hua Liang*, Weiping Cai*, Tao Shen*, Deficient IL-2 produced by activated CD56+ T cells contributed to impaired NK cell-mediated ADCC function in chronic HIV-1 infection. Frontiers in Immunology, 2019, 10:1647.
9. Hua Liang#, Zhaojun Duan, Dan Li, Dongliang Li, Zheng Wang, Li Ren, Tao Shen*, Yiming Shao*, Higher level of circulating monocyte-platelet aggregates correlated with viremia and increased sCD163 level in HIV-1 infection. Cellular & Molecular Immunology, 2015, 12(4): 435-443.
10. Tao Shen#, Sohee Kim, Jeong-su Do, Lu Wang, Chris Lantz, Joseph F. Urban, Graham Le Gros and Booki Min*. T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. International Immunology. 2008, 20(9):1201-1209.